Do you have to reach around a camera tripod as I did?:D.......I know what you mean, but it still gave me a chuckle; thanks!:)
Sorry friend, inclusive of "design, tolerance between the rod and hole, the angle of insertion required to make the insertion, shape of the breech end of the barrel and the spring tension" I'm just not having any issues inserting the guide rod and spring into a CW 45.
However, as you mention that a slightly rounded end would make the job much easier, I wonder if there is an issue with your guide rod.
Mine has the end beveled, perhaps yours isn't:
http://i54.tinypic.com/1yr1ic.jpg
Regards,
Greg