I'm setting up to start loading for the 50AE. I do load for other 500 calibers but with a semi-auto I think the DE will be more sensitive to pressures. The pressures on the big 500 are actually lower than one would think. My understanding is that plated lead bullets will result in lower pressure because the bullet is softer than a Jacketed bullet. I'd like to find out what minimum pressure the DE 50AE was designed to function at. Maybe MR can fill us in. My experience with the DE in 41 and 44 is that it functions better with loads in the mid to upper range of charge weights. I pretty much use Win 296 and H110 for Mag loads and make sure that my crimp and bullet tension is tight.With the 50AE it will head space on the edge of the shell so shell length will be more critical than OAL.